Effect of methylene blue on the disposition of ethanol.

نویسندگان

  • R Vonlanthen
  • J H Beer
  • B H Lauterburg
چکیده

The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [(14)C]ethanol to (14)CO(2) in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by the increase in the [lactate]/[pyruvate] ratio.

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عنوان ژورنال:
  • Alcohol and alcoholism

دوره 35 5  شماره 

صفحات  -

تاریخ انتشار 2000